diff --git a/Makefile b/Makefile
index 664ff230b..3a116678c 100644
--- a/Makefile
+++ b/Makefile
@@ -119,12 +119,20 @@ templates:
 	@# Need to prepend each line in the sample config with spaces in order to
 	@# fit correctly in the configmap spec.
 	@sed s'/^/    /' deployment/components/worker-config/nfd-worker.conf.example > nfd-worker.conf.tmp
+	@sed s'/^/    /' deployment/components/topology-updater-config/nfd-topology-updater.conf.example > nfd-topology-updater.conf.tmp
 	@# The sed magic below replaces the block of text between the lines with start and end markers
 	@start=NFD-WORKER-CONF-START-DO-NOT-REMOVE; \
 	end=NFD-WORKER-CONF-END-DO-NOT-REMOVE; \
 	sed -e "/$$start/,/$$end/{ /$$start/{ p; r nfd-worker.conf.tmp" \
 	    -e "}; /$$end/p; d }" -i deployment/helm/node-feature-discovery/values.yaml
+	@start=NFD-TOPOLOGY-UPDATER-CONF-START-DO-NOT-REMOVE; \
+	end=NFD-TOPOLOGY-UPDATER-CONF-END-DO-NOT-REMOVE; \
+	sed -e "/$$start/,/$$end/{ /$$start/{ p; r nfd-topology-updater.conf.tmp" \
+		-e "}; /$$end/p; d }" -i deployment/helm/node-feature-discovery/values.yaml
 	@rm nfd-worker.conf.tmp
+	@rm nfd-topology-updater.conf.tmp
+
+
 
 .generator.image.stamp: Dockerfile_generator
 	$(IMAGE_BUILD_CMD) \
diff --git a/cmd/nfd-topology-updater/main.go b/cmd/nfd-topology-updater/main.go
index bdb9b7c92..0b9bef9e8 100644
--- a/cmd/nfd-topology-updater/main.go
+++ b/cmd/nfd-topology-updater/main.go
@@ -155,6 +155,8 @@ func initFlags(flagset *flag.FlagSet) (*topology.Args, *resourcemonitor.Args) {
 		"NFD server address to connecto to.")
 	flagset.StringVar(&args.ServerNameOverride, "server-name-override", "",
 		"Hostname expected from server certificate, useful in testing")
+	flagset.StringVar(&args.ConfigFile, "config", "/etc/kubernetes/node-feature-discovery/nfd-topology-updater.conf",
+		"Config file to use.")
 
 	klog.InitFlags(flagset)
 
diff --git a/cmd/nfd-topology-updater/main_test.go b/cmd/nfd-topology-updater/main_test.go
index e1b249808..dd2ba86e0 100644
--- a/cmd/nfd-topology-updater/main_test.go
+++ b/cmd/nfd-topology-updater/main_test.go
@@ -34,19 +34,22 @@ func TestArgsParse(t *testing.T) {
 			Convey("noPublish is set and args.sources is set to the default value", func() {
 				So(args.NoPublish, ShouldBeTrue)
 				So(args.Oneshot, ShouldBeTrue)
+				So(args.ConfigFile, ShouldEqual, "/etc/kubernetes/node-feature-discovery/nfd-topology-updater.conf")
 				So(finderArgs.SleepInterval, ShouldEqual, 60*time.Second)
 				So(finderArgs.PodResourceSocketPath, ShouldEqual, "/var/lib/kubelet/pod-resources/kubelet.sock")
 			})
 		})
 
-		Convey("When valid args are specified for -kubelet-config-url and -sleep-interval,", func() {
+		Convey("When valid args are specified for -kubelet-config-url, -sleep-interval and -config,", func() {
 			args, finderArgs := parseArgs(flags,
 				"-kubelet-config-uri=file:///path/testconfig.yaml",
-				"-sleep-interval=30s")
+				"-sleep-interval=30s",
+				"-config=/path/nfd-topology-updater.conf")
 
 			Convey("args.sources is set to appropriate values", func() {
 				So(args.NoPublish, ShouldBeFalse)
 				So(args.Oneshot, ShouldBeFalse)
+				So(args.ConfigFile, ShouldEqual, "/path/nfd-topology-updater.conf")
 				So(finderArgs.SleepInterval, ShouldEqual, 30*time.Second)
 				So(finderArgs.KubeletConfigURI, ShouldEqual, "file:///path/testconfig.yaml")
 				So(finderArgs.PodResourceSocketPath, ShouldEqual, "/var/lib/kubelet/pod-resources/kubelet.sock")
diff --git a/deployment/components/topology-updater-config/kustomization.yaml b/deployment/components/topology-updater-config/kustomization.yaml
new file mode 100644
index 000000000..73644ab49
--- /dev/null
+++ b/deployment/components/topology-updater-config/kustomization.yaml
@@ -0,0 +1,10 @@
+apiVersion: kustomize.config.k8s.io/v1alpha1
+kind: Component
+
+generatorOptions:
+  disableNameSuffixHash: true
+
+configMapGenerator:
+- files:
+  - nfd-topology-updater.conf=nfd-topology-updater.conf.example
+  name: nfd-topology-updater-conf
diff --git a/deployment/components/topology-updater-config/nfd-topology-updater.conf.example b/deployment/components/topology-updater-config/nfd-topology-updater.conf.example
new file mode 100644
index 000000000..c244ba788
--- /dev/null
+++ b/deployment/components/topology-updater-config/nfd-topology-updater.conf.example
@@ -0,0 +1,7 @@
+## key = node name, value = list of resources to be excluded.
+## use * to exclude from all nodes.
+## an example for how the exclude list should looks like
+#excludeList:
+#  node1: [cpu]
+#  node2: [memory, example/deviceA]
+#  *: [hugepages-2Mi]
diff --git a/deployment/components/topology-updater/topologyupdater-mounts.yaml b/deployment/components/topology-updater/topologyupdater-mounts.yaml
index 89f1c2e5e..a098edf6c 100644
--- a/deployment/components/topology-updater/topologyupdater-mounts.yaml
+++ b/deployment/components/topology-updater/topologyupdater-mounts.yaml
@@ -10,6 +10,9 @@
   - name: kubelet-podresources-sock
     hostPath:
       path: /var/lib/kubelet/pod-resources/kubelet.sock
+  - name: nfd-topology-updater-conf
+    configMap:
+      name: nfd-topology-updater-conf
 
 - op: add
   path: /spec/template/spec/containers/0/volumeMounts
@@ -20,6 +23,9 @@
     mountPath: /host-var/lib/kubelet/pod-resources/kubelet.sock
   - name: host-sys
     mountPath: /host-sys
+  - name: nfd-topology-updater-conf
+    mountPath: "/etc/kubernetes/node-feature-discovery"
+    readOnly: true
 
 - op: add
   path: /spec/template/spec/containers/0/args/-
diff --git a/deployment/helm/node-feature-discovery/templates/nfd-topologyupdater-conf.yaml b/deployment/helm/node-feature-discovery/templates/nfd-topologyupdater-conf.yaml
new file mode 100644
index 000000000..9867f5089
--- /dev/null
+++ b/deployment/helm/node-feature-discovery/templates/nfd-topologyupdater-conf.yaml
@@ -0,0 +1,10 @@
+apiVersion: v1
+kind: ConfigMap
+metadata:
+  name: {{ include "node-feature-discovery.fullname" . }}-topology-updater-conf
+  namespace: {{ include "node-feature-discovery.namespace" . }}
+  labels:
+  {{- include "node-feature-discovery.labels" . | nindent 4 }}
+data:
+  nfd-topology-updater.conf: |-
+    {{- .Values.topologyUpdater.config | toYaml | nindent 4 }}
diff --git a/deployment/helm/node-feature-discovery/templates/topologyupdater.yaml b/deployment/helm/node-feature-discovery/templates/topologyupdater.yaml
index be48c5fe7..a53a6033c 100644
--- a/deployment/helm/node-feature-discovery/templates/topologyupdater.yaml
+++ b/deployment/helm/node-feature-discovery/templates/topologyupdater.yaml
@@ -68,6 +68,9 @@ spec:
           mountPath: "/etc/kubernetes/node-feature-discovery/certs"
           readOnly: true
         {{- end }}
+        - name: topology-updater-conf
+          mountPath: "/etc/kubernetes/node-feature-discovery"
+          readOnly: true
 
         resources:
       {{- toYaml .Values.topologyUpdater.resources | nindent 12 }}
@@ -91,12 +94,19 @@ spec:
           {{- else }}
           path: /var/lib/kubelet/pod-resources/kubelet.sock
           {{- end }}
+      - name: nfd-topology-updater-conf
+        configMap:
+          name: {{ include "node-feature-discovery.fullname" . }}-topology-updater-conf
+          items:
+            - key: nfd-topology-updater.conf
+              path: nfd-topology-updater.conf
       {{- if .Values.tls.enable }}
       - name: nfd-topology-updater-cert
         secret:
           secretName: nfd-topology-updater-cert
       {{- end }}
 
+
     {{- with .Values.topologyUpdater.nodeSelector }}
       nodeSelector:
         {{- toYaml . | nindent 8 }}
diff --git a/deployment/helm/node-feature-discovery/values.yaml b/deployment/helm/node-feature-discovery/values.yaml
index a052a8baa..477f16297 100644
--- a/deployment/helm/node-feature-discovery/values.yaml
+++ b/deployment/helm/node-feature-discovery/values.yaml
@@ -368,6 +368,16 @@ worker:
   priorityClassName: ""
 
 topologyUpdater:
+  config: ### <NFD-TOPOLOGY-UPDATER-CONF-START-DO-NOT-REMOVE>
+    ## key = node name, value = list of resources to be excluded.
+    ## use * to exclude from all nodes.
+    ## an example for how the exclude list should looks like
+    #excludeList:
+    #  node1: [cpu]
+    #  node2: [memory, example/deviceA]
+    #  *: [hugepages-2Mi]
+### <NFD-TOPOLOGY-UPDATER-CONF-END-DO-NOT-REMOVE>
+
   enable: false
   createCRDs: false
 
diff --git a/deployment/overlays/master-worker-topologyupdater/kustomization.yaml b/deployment/overlays/master-worker-topologyupdater/kustomization.yaml
index 0725d0c56..ffcbab658 100644
--- a/deployment/overlays/master-worker-topologyupdater/kustomization.yaml
+++ b/deployment/overlays/master-worker-topologyupdater/kustomization.yaml
@@ -19,3 +19,4 @@ components:
 - ../../components/worker-config
 - ../../components/common
 - ../../components/topology-updater
+- ../../components/topology-updater-config
diff --git a/deployment/overlays/topologyupdater/kustomization.yaml b/deployment/overlays/topologyupdater/kustomization.yaml
index 37b01ed76..e007b40a0 100644
--- a/deployment/overlays/topologyupdater/kustomization.yaml
+++ b/deployment/overlays/topologyupdater/kustomization.yaml
@@ -16,3 +16,4 @@ resources:
 components:
 - ../../components/common
 - ../../components/topology-updater
+- ../../components/topology-updater-config
diff --git a/docs/deployment/helm.md b/docs/deployment/helm.md
index 0cd584244..824f3c72b 100644
--- a/docs/deployment/helm.md
+++ b/docs/deployment/helm.md
@@ -142,24 +142,25 @@ We have introduced the following Chart parameters.
 
 ### Topology updater parameters
 
-| Name                                          | Type   | Default | description                                                                                                                                                                |
-|-----------------------------------------------|--------|---------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
-| `topologyUpdater.*`                           | dict   |         | NFD Topology Updater configuration                                                                                                                                         |
-| `topologyUpdater.enable`                      | bool   | false   | Specifies whether the NFD Topology Updater should be created                                                                                                               |
-| `topologyUpdater.createCRDs`                  | bool   | false   | Specifies whether the NFD Topology Updater CRDs should be created                                                                                                          |
-| `topologyUpdater.serviceAccount.create`       | bool   | true    | Specifies whether the service account for topology updater should be created                                                                                               |
-| `topologyUpdater.serviceAccount.annotations`  | dict   | {}      | Annotations to add to the service account for topology updater                                                                                                             |
-| `topologyUpdater.serviceAccount.name`         | string |         | The name of the service account for topology updater to use. If not set and create is true, a name is generated using the fullname template and `-topology-updater` suffix |
-| `topologyUpdater.rbac`                        | dict   |         | RBAC [parameters](https://kubernetes.io/docs/reference/access-authn-authz/rbac/) for the topology updater                                                                 |
-| `topologyUpdater.rbac.create`                 | bool   | false   | Specifies whether the cluster role and binding for topology updater should be created                                                                                      |
-| `topologyUpdater.kubeletConfigPath`           | string | ""      | Specifies the kubelet config host path                                                                                                                                     |
-| `topologyUpdater.kubeletPodResourcesSockPath` | string | ""      | Specifies the kubelet sock path to read pod resources                                                                                                                      |
-| `topologyUpdater.updateInterval`              | string | 60s     | Time to sleep between CR updates. Non-positive value implies no CR update.                                                                                                 |
-| `topologyUpdater.watchNamespace`              | string | `*`     | Namespace to watch pods, `*` for all namespaces                                                                                                                            |
-| `topologyUpdater.podSecurityContext`          | dict   | {}      | [PodSecurityContext](https://kubernetes.io/docs/tasks/configure-pod-container/security-context/#set-the-security-context-for-a-pod) holds pod-level security attributes and common container settings                                                                                          |
-| `topologyUpdater.securityContext`             | dict   | {}      | Container [security settings](https://kubernetes.io/docs/tasks/configure-pod-container/security-context/#set-the-security-context-for-a-container)                         |
-| `topologyUpdater.resources`                   | dict   | {}      | Topology updater pod [resources management](https://kubernetes.io/docs/concepts/configuration/manage-resources-containers/)                                                |
-| `topologyUpdater.nodeSelector`                | dict   | {}      | Topology updater pod [node selector](https://kubernetes.io/docs/concepts/scheduling-eviction/assign-pod-node/#nodeselector)                                                |
-| `topologyUpdater.tolerations`                 | dict   | {}      | Topology updater pod [node tolerations](https://kubernetes.io/docs/concepts/scheduling-eviction/taint-and-toleration/)                                                     |
-| `topologyUpdater.annotations`                 | dict   | {}      | Topology updater pod [annotations](https://kubernetes.io/docs/concepts/overview/working-with-objects/annotations/)                                                            |
-| `topologyUpdater.affinity`                    | dict   | {}      | Topology updater pod [affinity](https://kubernetes.io/docs/tasks/configure-pod-container/assign-pods-nodes-using-node-affinity/)                                           |
+| Name                                          | Type   | Default | description                                                                                                                                                                                           |
+|-----------------------------------------------|--------|---------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
+| `topologyUpdater.*`                           | dict   |         | NFD Topology Updater configuration                                                                                                                                                                    |
+| `topologyUpdater.enable`                      | bool   | false   | Specifies whether the NFD Topology Updater should be created                                                                                                                                          |
+| `topologyUpdater.createCRDs`                  | bool   | false   | Specifies whether the NFD Topology Updater CRDs should be created                                                                                                                                     |
+| `topologyUpdater.serviceAccount.create`       | bool   | true    | Specifies whether the service account for topology updater should be created                                                                                                                          |
+| `topologyUpdater.serviceAccount.annotations`  | dict   | {}      | Annotations to add to the service account for topology updater                                                                                                                                        |
+| `topologyUpdater.serviceAccount.name`         | string |         | The name of the service account for topology updater to use. If not set and create is true, a name is generated using the fullname template and `-topology-updater` suffix                            |
+| `topologyUpdater.rbac`                        | dict   |         | RBAC [parameters](https://kubernetes.io/docs/reference/access-authn-authz/rbac/) for the topology updater                                                                                             |
+| `topologyUpdater.rbac.create`                 | bool   | false   | Specifies whether the cluster role and binding for topology updater should be created                                                                                                                 |
+| `topologyUpdater.kubeletConfigPath`           | string | ""      | Specifies the kubelet config host path                                                                                                                                                                |
+| `topologyUpdater.kubeletPodResourcesSockPath` | string | ""      | Specifies the kubelet sock path to read pod resources                                                                                                                                                 |
+| `topologyUpdater.updateInterval`              | string | 60s     | Time to sleep between CR updates. Non-positive value implies no CR update.                                                                                                                            |
+| `topologyUpdater.watchNamespace`              | string | `*`     | Namespace to watch pods, `*` for all namespaces                                                                                                                                                       |
+| `topologyUpdater.podSecurityContext`          | dict   | {}      | [PodSecurityContext](https://kubernetes.io/docs/tasks/configure-pod-container/security-context/#set-the-security-context-for-a-pod) holds pod-level security attributes and common container settings |
+| `topologyUpdater.securityContext`             | dict   | {}      | Container [security settings](https://kubernetes.io/docs/tasks/configure-pod-container/security-context/#set-the-security-context-for-a-container)                                                    |
+| `topologyUpdater.resources`                   | dict   | {}      | Topology updater pod [resources management](https://kubernetes.io/docs/concepts/configuration/manage-resources-containers/)                                                                           |
+| `topologyUpdater.nodeSelector`                | dict   | {}      | Topology updater pod [node selector](https://kubernetes.io/docs/concepts/scheduling-eviction/assign-pod-node/#nodeselector)                                                                           |
+| `topologyUpdater.tolerations`                 | dict   | {}      | Topology updater pod [node tolerations](https://kubernetes.io/docs/concepts/scheduling-eviction/taint-and-toleration/)                                                                                |
+| `topologyUpdater.annotations`                 | dict   | {}      | Topology updater pod [annotations](https://kubernetes.io/docs/concepts/overview/working-with-objects/annotations/)                                                                                    |
+| `topologyUpdater.affinity`                    | dict   | {}      | Topology updater pod [affinity](https://kubernetes.io/docs/tasks/configure-pod-container/assign-pods-nodes-using-node-affinity/)                                                                      |
+| `topologyUpdater.config`                      | dict   |         | [configuration](../reference/topology-updater-configuration-reference)                                                                                                                                |
diff --git a/docs/reference/topology-updater-commandline-reference.md b/docs/reference/topology-updater-commandline-reference.md
index 742d36c66..197d95042 100644
--- a/docs/reference/topology-updater-commandline-reference.md
+++ b/docs/reference/topology-updater-commandline-reference.md
@@ -21,7 +21,8 @@ To quickly view available command line flags execute `nfd-topology-updater -help
 In a docker container:
 
 ```bash
-docker run gcr.io/k8s-staging-nfd/node-feature-discovery:master nfd-topology-updater -help
+docker run {{ site.container_image }} \
+nfd-topology-updater -help
 ```
 
 ### -h, -help
@@ -32,6 +33,19 @@ Print usage and exit.
 
 Print version and exit.
 
+### -config
+
+The `-config` flag specifies the path of the nfd-topology-updater
+configuration file to use.
+
+Default: /etc/kubernetes/node-feature-discovery/nfd-topology-updater.conf
+
+Example:
+
+```bash
+nfd-topology-updater -config=/opt/nfd/nfd-topology-updater.conf
+```
+
 ### -server
 
 The `-server` flag specifies the address of the nfd-master endpoint where to
diff --git a/docs/reference/topology-updater-configuration-reference.md b/docs/reference/topology-updater-configuration-reference.md
new file mode 100644
index 000000000..cda081452
--- /dev/null
+++ b/docs/reference/topology-updater-configuration-reference.md
@@ -0,0 +1,52 @@
+---
+title: "Topology-Updater config reference"
+layout: default
+sort: 5
+---
+
+# Configuration file reference of nfd-topology-updater
+{: .no_toc}
+
+## Table of contents
+{: .no_toc .text-delta}
+
+1. TOC
+{:toc}
+
+---
+
+See the
+[sample configuration file](https://github.com/kubernetes-sigs/node-feature-discovery/blob/{{site.release}}/deployment/components/topology-updater-config/nfd-topology-updater.conf.example)
+for a full example configuration.
+
+## excludeList
+
+The `excludeList` specifies a key-value map of allocated resources
+that should not be examined by the topology-updater
+agent per node.
+Each key is a node name with a value as a list of resources
+that should not be examined by the agent for that specific node.
+
+Default: *empty*
+
+Example:
+
+```yaml
+excludeList:
+  nodeA: [hugepages-2Mi]
+  nodeB: [memory]
+  nodeC: [cpu, hugepages-2Mi]
+```
+
+### excludeList.*
+`excludeList.*` is a special value that use to specify all nodes.
+A resource that would be listed under this key, would be excluded from all nodes.
+
+Default: *empty*
+
+Example:
+
+```yaml
+excludeList:
+  '*': [hugepages-2Mi]
+```
diff --git a/docs/usage/nfd-topology-updater.md b/docs/usage/nfd-topology-updater.md
index fab56715c..353b43d9a 100644
--- a/docs/usage/nfd-topology-updater.md
+++ b/docs/usage/nfd-topology-updater.md
@@ -20,5 +20,42 @@ When run as a daemonset, nodes are re-examined for the allocated resources
 (to determine the information of the allocatable resources on a per zone basis
 where a zone can be a NUMA node) at an interval specified using the
 [`-sleep-interval`](../reference/topology-updater-commandline-reference.html#-sleep-interval)
-option. The default sleep interval is set to 60s which is the the value when no
+option. The default sleep interval is set to 60s which is the value when no
 -sleep-interval is specified.
+In addition, it can avoid examining specific allocated resources
+given a configuration of resources to exclude via [`-excludeList`](../reference/topology-updater-configuration-reference.md#excludelist)
+
+## Topology-Updater Configuration
+
+NFD-Topology-Updater supports configuration through a configuration file. The
+default location is `/etc/kubernetes/node-feature-discovery/topology-updater.conf`,
+but, this can be changed by specifying the`-config` command line flag.
+> NOTE: unlike nfd-worker,
+> dynamic configuration updates are not currently supported.
+
+Topology-Updater configuration file is read inside the container,
+and thus, Volumes and VolumeMounts are needed
+to make your configuration available for NFD.
+The preferred method is to use a ConfigMap
+which provides easy deployment and re-configurability.
+
+The provided nfd-topology-updater deployment templates
+create an empty configmap
+and mount it inside the nfd-topology-updater containers.
+In kustomize deployments, configuration can be edited with:
+
+```bash
+kubectl -n ${NFD_NS} edit configmap nfd-topology-updater-conf
+```
+
+In Helm deployments,
+[Topology Updater parameters](../deployment/helm.md#topology-updater-parameters)
+`toplogyUpdater.config` can be used to edit the respective configuration.
+
+See
+[nfd-topology-updater configuration file reference](../reference/topology-updater-configuration-reference.md)
+for more details.
+The (empty-by-default)
+[example config](https://github.com/kubernetes-sigs/node-feature-discovery/blob/{{site.release}}/deployment/components/topology-updater-config/nfd-topology-updater.conf.example)
+contains all available configuration options and can be used as a reference
+for creating a configuration.
\ No newline at end of file
diff --git a/docs/usage/nfd-worker.md b/docs/usage/nfd-worker.md
index 6a22eb330..4a662dbf7 100644
--- a/docs/usage/nfd-worker.md
+++ b/docs/usage/nfd-worker.md
@@ -62,7 +62,7 @@ for more details.
 The (empty-by-default)
 [example config](https://github.com/kubernetes-sigs/node-feature-discovery/blob/{{site.release}}/deployment/components/worker-config/nfd-worker.conf.example)
 contains all available configuration options and can be used as a reference
-for creating creating a configuration.
+for creating a configuration.
 
 Configuration options can also be specified via the `-options` command line
 flag, in which case no mounts need to be used. The same format as in the config
diff --git a/pkg/nfd-client/topology-updater/nfd-topology-updater.go b/pkg/nfd-client/topology-updater/nfd-topology-updater.go
index baa8f378e..1853536e2 100644
--- a/pkg/nfd-client/topology-updater/nfd-topology-updater.go
+++ b/pkg/nfd-client/topology-updater/nfd-topology-updater.go
@@ -18,6 +18,8 @@ package topologyupdater
 
 import (
 	"fmt"
+	"os"
+	"path/filepath"
 	"time"
 
 	"k8s.io/klog/v2"
@@ -32,6 +34,7 @@ import (
 	pb "sigs.k8s.io/node-feature-discovery/pkg/topologyupdater"
 	"sigs.k8s.io/node-feature-discovery/pkg/utils"
 	"sigs.k8s.io/node-feature-discovery/pkg/version"
+	"sigs.k8s.io/yaml"
 )
 
 // Args are the command line arguments
@@ -40,6 +43,12 @@ type Args struct {
 	NoPublish      bool
 	Oneshot        bool
 	KubeConfigFile string
+	ConfigFile     string
+}
+
+// NFDConfig contains the configuration settings of NFDTopologyUpdater.
+type NFDConfig struct {
+	ExcludeList map[string][]string
 }
 
 type NfdTopologyUpdater interface {
@@ -59,6 +68,8 @@ type nfdTopologyUpdater struct {
 	certWatch           *utils.FsWatcher
 	client              pb.NodeTopologyClient
 	stop                chan struct{} // channel for signaling stop
+	configFilePath      string
+	config              *NFDConfig
 }
 
 // NewTopologyUpdater creates a new NfdTopologyUpdater instance.
@@ -75,7 +86,11 @@ func NewTopologyUpdater(args Args, resourcemonitorArgs resourcemonitor.Args, pol
 		nodeInfo: &staticNodeInfo{
 			tmPolicy: policy,
 		},
-		stop: make(chan struct{}, 1),
+		stop:   make(chan struct{}, 1),
+		config: &NFDConfig{},
+	}
+	if args.ConfigFile != "" {
+		nfd.configFilePath = filepath.Clean(args.ConfigFile)
 	}
 	return nfd, nil
 }
@@ -99,6 +114,9 @@ func (w *nfdTopologyUpdater) Run() error {
 		}
 		kubeApihelper = apihelper.K8sHelpers{Kubeconfig: kubeconfig}
 	}
+	if err := w.configure(); err != nil {
+		return fmt.Errorf("faild to configure Node Feature Discovery Topology Updater: %w", err)
+	}
 
 	var resScan resourcemonitor.ResourcesScanner
 
@@ -113,7 +131,8 @@ func (w *nfdTopologyUpdater) Run() error {
 	// zonesChannel := make(chan v1alpha1.ZoneList)
 	var zones v1alpha1.ZoneList
 
-	resAggr, err := resourcemonitor.NewResourcesAggregator(podResClient)
+	excludeList := resourcemonitor.NewExcludeResourceList(w.config.ExcludeList, nfdclient.NodeName())
+	resAggr, err := resourcemonitor.NewResourcesAggregator(podResClient, excludeList)
 	if err != nil {
 		return fmt.Errorf("failed to obtain node resource information: %w", err)
 	}
@@ -245,3 +264,27 @@ func advertiseNodeTopology(client pb.NodeTopologyClient, zoneInfo v1alpha1.ZoneL
 
 	return nil
 }
+
+func (w *nfdTopologyUpdater) configure() error {
+	if w.configFilePath == "" {
+		klog.Warningf("file path for nfd-topology-updater conf file is empty")
+		return nil
+	}
+
+	b, err := os.ReadFile(w.configFilePath)
+	if err != nil {
+		// config is optional
+		if os.IsNotExist(err) {
+			klog.Warningf("couldn't find conf file under %v", w.configFilePath)
+			return nil
+		}
+		return err
+	}
+
+	err = yaml.Unmarshal(b, w.config)
+	if err != nil {
+		return fmt.Errorf("failed to parse configuration file %q: %w", w.configFilePath, err)
+	}
+	klog.Infof("configuration file %q parsed:\n %v", w.configFilePath, w.config)
+	return nil
+}
diff --git a/pkg/resourcemonitor/excludelist.go b/pkg/resourcemonitor/excludelist.go
new file mode 100644
index 000000000..444042f46
--- /dev/null
+++ b/pkg/resourcemonitor/excludelist.go
@@ -0,0 +1,33 @@
+package resourcemonitor
+
+import (
+	corev1 "k8s.io/api/core/v1"
+	"k8s.io/apimachinery/pkg/util/sets"
+	"k8s.io/klog/v2"
+)
+
+// ExcludeResourceList contains a list of resources to ignore during resources scan
+type ExcludeResourceList struct {
+	excludeList sets.String
+}
+
+// NewExcludeResourceList returns new ExcludeList with values with set.String types
+func NewExcludeResourceList(resMap map[string][]string, nodeName string) ExcludeResourceList {
+	excludeList := make(sets.String)
+	for k, v := range resMap {
+		if k == nodeName || k == "*" {
+			excludeList.Insert(v...)
+		}
+	}
+	return ExcludeResourceList{
+		excludeList: excludeList,
+	}
+}
+
+func (rl *ExcludeResourceList) IsExcluded(resource corev1.ResourceName) bool {
+	if rl.excludeList.Has(string(resource)) {
+		klog.V(5).InfoS("resource excluded", "resource", resource)
+		return true
+	}
+	return false
+}
diff --git a/pkg/resourcemonitor/excludelist_test.go b/pkg/resourcemonitor/excludelist_test.go
new file mode 100644
index 000000000..092d1da42
--- /dev/null
+++ b/pkg/resourcemonitor/excludelist_test.go
@@ -0,0 +1,70 @@
+package resourcemonitor
+
+import (
+	"testing"
+
+	corev1 "k8s.io/api/core/v1"
+)
+
+const (
+	cpu             = string(corev1.ResourceCPU)
+	memory          = string(corev1.ResourceMemory)
+	hugepages2Mi    = "hugepages-2Mi"
+	nicResourceName = "vendor/nic1"
+)
+
+func TestNewExcludeResourceList(t *testing.T) {
+	tests := []struct {
+		desc                      string
+		excludeListConfig         map[string][]string
+		nodeName                  string
+		expectedExcludedResources []string
+	}{
+		{
+
+			desc: "exclude list with multiple nodes",
+			excludeListConfig: map[string][]string{
+				"node1": {
+					cpu,
+					nicResourceName,
+				},
+				"node2": {
+					memory,
+					hugepages2Mi,
+				},
+			},
+			nodeName:                  "node1",
+			expectedExcludedResources: []string{cpu, nicResourceName},
+		},
+		{
+			desc: "exclude list with wild card",
+			excludeListConfig: map[string][]string{
+				"*": {
+					memory, nicResourceName,
+				},
+				"node1": {
+					cpu,
+					hugepages2Mi,
+				},
+			},
+			nodeName:                  "node2",
+			expectedExcludedResources: []string{memory, nicResourceName},
+		},
+		{
+			desc:                      "empty exclude list",
+			excludeListConfig:         map[string][]string{},
+			nodeName:                  "node1",
+			expectedExcludedResources: []string{},
+		},
+	}
+
+	for _, tt := range tests {
+		t.Logf("test %s", tt.desc)
+		excludeList := NewExcludeResourceList(tt.excludeListConfig, tt.nodeName)
+		for _, res := range tt.expectedExcludedResources {
+			if !excludeList.IsExcluded(corev1.ResourceName(res)) {
+				t.Errorf("resource: %q expected to be excluded from node: %q", res, tt.nodeName)
+			}
+		}
+	}
+}
diff --git a/pkg/resourcemonitor/noderesourcesaggregator.go b/pkg/resourcemonitor/noderesourcesaggregator.go
index 8b08c33ae..12d4676f2 100644
--- a/pkg/resourcemonitor/noderesourcesaggregator.go
+++ b/pkg/resourcemonitor/noderesourcesaggregator.go
@@ -28,8 +28,8 @@ import (
 	corev1 "k8s.io/api/core/v1"
 	"k8s.io/apimachinery/pkg/api/resource"
 	"k8s.io/klog/v2"
-	podresourcesapi "k8s.io/kubelet/pkg/apis/podresources/v1"
 
+	podresourcesapi "k8s.io/kubelet/pkg/apis/podresources/v1"
 	"sigs.k8s.io/node-feature-discovery/pkg/utils"
 	"sigs.k8s.io/node-feature-discovery/pkg/utils/hostpath"
 )
@@ -46,6 +46,7 @@ type nodeResources struct {
 	topo                           *ghw.TopologyInfo
 	reservedCPUIDPerNUMA           map[int][]string
 	memoryResourcesCapacityPerNUMA utils.NumaMemoryResources
+	excludeList                    ExcludeResourceList
 }
 
 type resourceData struct {
@@ -54,7 +55,7 @@ type resourceData struct {
 	capacity    int64
 }
 
-func NewResourcesAggregator(podResourceClient podresourcesapi.PodResourcesListerClient) (ResourcesAggregator, error) {
+func NewResourcesAggregator(podResourceClient podresourcesapi.PodResourcesListerClient, excludeList ExcludeResourceList) (ResourcesAggregator, error) {
 	var err error
 
 	topo, err := ghw.Topology(ghw.WithPathOverrides(ghw.PathOverrides{
@@ -85,11 +86,11 @@ func NewResourcesAggregator(podResourceClient podresourcesapi.PodResourcesLister
 		return nil, fmt.Errorf("failed to get allocatable resources (ensure that KubeletPodResourcesGetAllocatable feature gate is enabled): %w", err)
 	}
 
-	return NewResourcesAggregatorFromData(topo, resp, memoryResourcesCapacityPerNUMA), nil
+	return NewResourcesAggregatorFromData(topo, resp, memoryResourcesCapacityPerNUMA, excludeList), nil
 }
 
 // NewResourcesAggregatorFromData is used to aggregate resource information based on the received data from underlying hardware and podresource API
-func NewResourcesAggregatorFromData(topo *ghw.TopologyInfo, resp *podresourcesapi.AllocatableResourcesResponse, memoryResourceCapacity utils.NumaMemoryResources) ResourcesAggregator {
+func NewResourcesAggregatorFromData(topo *ghw.TopologyInfo, resp *podresourcesapi.AllocatableResourcesResponse, memoryResourceCapacity utils.NumaMemoryResources, excludeList ExcludeResourceList) ResourcesAggregator {
 	allDevs := getContainerDevicesFromAllocatableResources(resp, topo)
 	return &nodeResources{
 		topo:                           topo,
@@ -97,6 +98,7 @@ func NewResourcesAggregatorFromData(topo *ghw.TopologyInfo, resp *podresourcesap
 		perNUMAAllocatable:             makeNodeAllocatable(allDevs, resp.GetMemory()),
 		reservedCPUIDPerNUMA:           makeReservedCPUMap(topo.Nodes, allDevs),
 		memoryResourcesCapacityPerNUMA: memoryResourceCapacity,
+		excludeList:                    excludeList,
 	}
 }
 
@@ -108,6 +110,9 @@ func (noderesourceData *nodeResources) Aggregate(podResData []PodResources) topo
 		if ok {
 			perNuma[nodeID] = make(map[corev1.ResourceName]*resourceData)
 			for resName, allocatable := range nodeRes {
+				if noderesourceData.excludeList.IsExcluded(resName) {
+					continue
+				}
 				switch {
 				case resName == "cpu":
 					perNuma[nodeID][resName] = &resourceData{
diff --git a/pkg/resourcemonitor/noderesourcesaggregator_test.go b/pkg/resourcemonitor/noderesourcesaggregator_test.go
index a5ddeca89..011c14de9 100644
--- a/pkg/resourcemonitor/noderesourcesaggregator_test.go
+++ b/pkg/resourcemonitor/noderesourcesaggregator_test.go
@@ -178,7 +178,7 @@ func TestResourcesAggregator(t *testing.T) {
 				corev1.ResourceName("hugepages-2Mi"): 2048,
 			},
 		}
-		resAggr = NewResourcesAggregatorFromData(&fakeTopo, availRes, memoryResourcesCapacity)
+		resAggr = NewResourcesAggregatorFromData(&fakeTopo, availRes, memoryResourcesCapacity, NewExcludeResourceList(map[string][]string{}, ""))
 
 		Convey("When aggregating resources", func() {
 			expected := topologyv1alpha1.ZoneList{
@@ -376,7 +376,7 @@ func TestResourcesAggregator(t *testing.T) {
 			},
 		}
 
-		resAggr = NewResourcesAggregatorFromData(&fakeTopo, availRes, memoryResourcesCapacity)
+		resAggr = NewResourcesAggregatorFromData(&fakeTopo, availRes, memoryResourcesCapacity, NewExcludeResourceList(map[string][]string{}, ""))
 
 		Convey("When aggregating resources", func() {
 			podRes := []PodResources{
diff --git a/test/e2e/topology_updater.go b/test/e2e/topology_updater.go
index 0d8a43501..375c84fea 100644
--- a/test/e2e/topology_updater.go
+++ b/test/e2e/topology_updater.go
@@ -27,6 +27,7 @@ import (
 	"github.com/k8stopologyawareschedwg/noderesourcetopology-api/pkg/apis/topology/v1alpha1"
 	topologyclientset "github.com/k8stopologyawareschedwg/noderesourcetopology-api/pkg/generated/clientset/versioned"
 
+	appsv1 "k8s.io/api/apps/v1"
 	corev1 "k8s.io/api/core/v1"
 	extclient "k8s.io/apiextensions-apiserver/pkg/client/clientset/clientset"
 	metav1 "k8s.io/apimachinery/pkg/apis/meta/v1"
@@ -42,16 +43,17 @@ import (
 
 var _ = SIGDescribe("Node Feature Discovery topology updater", func() {
 	var (
-		extClient           *extclient.Clientset
-		topologyClient      *topologyclientset.Clientset
-		topologyUpdaterNode *corev1.Node
-		workerNodes         []corev1.Node
-		kubeletConfig       *kubeletconfig.KubeletConfiguration
+		extClient                *extclient.Clientset
+		topologyClient           *topologyclientset.Clientset
+		topologyUpdaterNode      *corev1.Node
+		topologyUpdaterDaemonSet *appsv1.DaemonSet
+		workerNodes              []corev1.Node
+		kubeletConfig            *kubeletconfig.KubeletConfiguration
 	)
 
 	f := framework.NewDefaultFramework("node-topology-updater")
 	f.NamespacePodSecurityEnforceLevel = admissionapi.LevelPrivileged
-	BeforeEach(func() {
+	JustBeforeEach(func() {
 		var err error
 
 		if extClient == nil {
@@ -64,18 +66,10 @@ var _ = SIGDescribe("Node Feature Discovery topology updater", func() {
 			Expect(err).NotTo(HaveOccurred())
 		}
 
-		cfg, err := testutils.GetConfig()
-		Expect(err).ToNot(HaveOccurred())
-
-		kcfg := cfg.GetKubeletConfig()
-		By(fmt.Sprintf("Using config (%#v)", kcfg))
-
 		By("Creating the node resource topologies CRD")
-		_, err = testutils.CreateNodeResourceTopologies(extClient)
-		Expect(err).NotTo(HaveOccurred())
+		Expect(testutils.CreateNodeResourceTopologies(extClient)).ToNot(BeNil())
 
-		err = testutils.ConfigureRBAC(f.ClientSet, f.Namespace.Name)
-		Expect(err).NotTo(HaveOccurred())
+		Expect(testutils.ConfigureRBAC(f.ClientSet, f.Namespace.Name)).NotTo(HaveOccurred())
 
 		image := fmt.Sprintf("%s:%s", *dockerRepo, *dockerTag)
 		f.PodClient().CreateSync(testutils.NFDMasterPod(image, false))
@@ -88,7 +82,6 @@ var _ = SIGDescribe("Node Feature Discovery topology updater", func() {
 		Expect(e2enetwork.WaitForService(f.ClientSet, f.Namespace.Name, masterService.Name, true, time.Second, 10*time.Second)).NotTo(HaveOccurred())
 
 		By("Creating nfd-topology-updater daemonset")
-		topologyUpdaterDaemonSet := testutils.NFDTopologyUpdaterDaemonSet(kcfg, fmt.Sprintf("%s:%s", *dockerRepo, *dockerTag), []string{})
 		topologyUpdaterDaemonSet, err = f.ClientSet.AppsV1().DaemonSets(f.Namespace.Name).Create(context.TODO(), topologyUpdaterDaemonSet, metav1.CreateOptions{})
 		Expect(err).NotTo(HaveOccurred())
 
@@ -110,7 +103,25 @@ var _ = SIGDescribe("Node Feature Discovery topology updater", func() {
 		Expect(err).NotTo(HaveOccurred())
 	})
 
+	// TODO: replace with regular AfterEach once we have https://github.com/kubernetes/kubernetes/pull/111998 in
+	f.AddAfterEach("Node Feature Discovery topology updater CRD and RBAC removal", func(f *framework.Framework, failed bool) {
+		err := testutils.DeconfigureRBAC(f.ClientSet, f.Namespace.Name)
+		if err != nil {
+			framework.Logf("failed to delete RBAC resources: %v", err)
+		}
+	})
+
 	Context("with single nfd-master pod", func() {
+		BeforeEach(func() {
+			cfg, err := testutils.GetConfig()
+			Expect(err).ToNot(HaveOccurred())
+
+			kcfg := cfg.GetKubeletConfig()
+			By(fmt.Sprintf("Using config (%#v)", kcfg))
+
+			topologyUpdaterDaemonSet = testutils.NFDTopologyUpdaterDaemonSet(kcfg, fmt.Sprintf("%s:%s", *dockerRepo, *dockerTag), []string{})
+		})
+
 		It("should fill the node resource topologies CR with the data", func() {
 			nodeTopology := testutils.GetNodeTopology(topologyClient, topologyUpdaterNode.Name)
 			isValid := testutils.IsValidNodeTopology(nodeTopology, kubeletConfig)
@@ -247,11 +258,50 @@ var _ = SIGDescribe("Node Feature Discovery topology updater", func() {
 
 	})
 
-	JustAfterEach(func() {
-		err := testutils.DeconfigureRBAC(f.ClientSet, f.Namespace.Name)
-		if err != nil {
-			framework.Logf("failed to delete RBAC resources: %v", err)
-		}
+	When("topology-updater configure to exclude memory", func() {
+		var topologyUpdaterConfigMap *corev1.ConfigMap
+
+		BeforeEach(func() {
+			data := make(map[string]string)
+			data["nfd-topology-updater.conf"] = `excludeList:
+  '*': [memory]
+`
+			topologyUpdaterConfigMap = &corev1.ConfigMap{
+				ObjectMeta: metav1.ObjectMeta{
+					Name: "nfd-topology-updater-conf",
+				},
+				Data: data,
+			}
+
+			cm, err := f.ClientSet.CoreV1().ConfigMaps(f.Namespace.Name).Create(context.TODO(), topologyUpdaterConfigMap, metav1.CreateOptions{})
+			Expect(err).ToNot(HaveOccurred())
+
+			cfg, err := testutils.GetConfig()
+			Expect(err).ToNot(HaveOccurred())
+
+			kcfg := cfg.GetKubeletConfig()
+			By(fmt.Sprintf("Using config (%#v)", kcfg))
+
+			opts := testutils.SpecWithConfigMap(cm.Name, cm.Name, "/etc/kubernetes/node-feature-discovery")
+			topologyUpdaterDaemonSet = testutils.NFDTopologyUpdaterDaemonSet(kcfg, fmt.Sprintf("%s:%s", *dockerRepo, *dockerTag), []string{}, opts)
+		})
+
+		It("noderesourcetopology should not advertise the memory resource", func() {
+			Eventually(func() bool {
+				memoryFound := false
+				nodeTopology := testutils.GetNodeTopology(topologyClient, topologyUpdaterNode.Name)
+				for _, zone := range nodeTopology.Zones {
+					for _, res := range zone.Resources {
+						if res.Name == string(corev1.ResourceMemory) {
+							memoryFound = true
+							framework.Logf("resource:%s was found for nodeTopology:%s on zone:%s while it should not", corev1.ResourceMemory, nodeTopology.Name, zone.Name)
+							break
+						}
+					}
+				}
+				return memoryFound
+			}, 1*time.Minute, 10*time.Second).Should(BeFalse())
+		})
 	})
 })
 
diff --git a/test/e2e/utils/pod.go b/test/e2e/utils/pod.go
index fd6c0c43e..f1db373b9 100644
--- a/test/e2e/utils/pod.go
+++ b/test/e2e/utils/pod.go
@@ -176,11 +176,37 @@ func NFDWorkerDaemonSet(image string, extraArgs []string) *appsv1.DaemonSet {
 }
 
 // NFDTopologyUpdaterDaemonSet provides the NFD daemon set topology updater
-func NFDTopologyUpdaterDaemonSet(kc KubeletConfig, image string, extraArgs []string) *appsv1.DaemonSet {
+func NFDTopologyUpdaterDaemonSet(kc KubeletConfig, image string, extraArgs []string, options ...func(spec *corev1.PodSpec)) *appsv1.DaemonSet {
 	podSpec := nfdTopologyUpdaterPodSpec(kc, image, extraArgs)
+	for _, o := range options {
+		o(podSpec)
+	}
 	return newDaemonSet("nfd-topology-updater", podSpec)
 }
 
+func SpecWithConfigMap(cmName, volumeName, mountPath string) func(spec *corev1.PodSpec) {
+	return func(spec *corev1.PodSpec) {
+		spec.Volumes = append(spec.Volumes,
+			corev1.Volume{
+				Name: volumeName,
+				VolumeSource: corev1.VolumeSource{
+					ConfigMap: &corev1.ConfigMapVolumeSource{
+						LocalObjectReference: corev1.LocalObjectReference{
+							Name: cmName,
+						},
+					},
+				},
+			})
+		cnt := &spec.Containers[0]
+		cnt.VolumeMounts = append(cnt.VolumeMounts,
+			corev1.VolumeMount{
+				Name:      volumeName,
+				ReadOnly:  true,
+				MountPath: mountPath,
+			})
+	}
+}
+
 // newDaemonSet provide the new daemon set
 func newDaemonSet(name string, podSpec *corev1.PodSpec) *appsv1.DaemonSet {
 	return &appsv1.DaemonSet{